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    Metabolic Risk For Cardiovascular Disease

    Original price was: $159.00.Current price is: $120.00.

    Metabolic Risk For Cardiovascular Disease

    by Robert H. Eckel (Editor)
    The relationship of metabolic diseases to cardiovascular disease (CVD) is reaching epidemic proportions. This relates mostly to the increasing prevalence of obesity, the metabolic syndrome and type 2 diabetes.This book outlines and addresses the metabolic factors and related diseases that contribute to CVD, including brief introductions to metabolic pathways including lipid and lipoprotein metabolism, macronutrient fuel partitioning, insulin action and body weight regulation. Mechanisms that relate to becoming obese, maintenance of the obese state, the dyslipidemias, and glucose intolerance/diabetes are also addressed, and the importance of interventions that reduce metabolic risk factors and CVD are covered.
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    Nutritional and Metabolic Bases of Cardiovascular Disease

    Original price was: $199.00.Current price is: $150.00.

    Nutritional and Metabolic Bases of Cardiovascular Disease

    Extraordinary advances in the understanding of the links between nutrition, metabolism, and cardiovascular disease have prompted a systematic reappraisal of knowledge in the field. As a result, it is now imperative that clinicians who care for patients with CVD or its key risk factors have a solid understanding of the often complex interrelationships between cardiovascular health and chronic diseases such as diabetes and obesity.Written by a team of international thought leaders in cardiology, endocrinology, diabetology and nutritional science, this important new book:
    • Examines and updates the role of obesity, hyperlipidemia, diabetes, hypertension, thrombosis, and aging in atherogenesis
    • Describes in detail the scientific and clinical evidence of the etiopathogenesis of ischemic heart disease as well as of peripheral and cerebrovascular disease
    • Focuses on the 6 topics that will be of greatest interest to readers: 1) general nutrition, 2) metabolic syndrome and diabetes, 3) hyperlipidemia and atherosclerosis, 4) hypertension and cerebrovascular disease, 5) hemostasis and thrombosis, 6) aging
    Throughout the book, in clear and accessible text, contributors illuminate the close relationship between dietary habits, the metabolic processes of nutrients, and their impact on the cardiovascular system, always with an eye on how the physician can use this information to implement better cardiovascular prevention and improve  patient care. Nutritional and Metabolic Bases of Cardiovascular Disease is ideal for those who need to update their knowledge of the links between nutrition, metabolism and CVD, from trainees, clinicians and clinical investigators in cardiovascular medicine to endocrinologists, diabetologists, and nutritionists.
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    Regenerating the Heart Stem Cells and the Cardiovascular System

    Original price was: $299.00.Current price is: $240.00.

    Regenerating the Heart Stem Cells and the Cardiovascular System

    by Ira S. Cohen  (Editor), Glenn R. Gaudette (Editor) Medical research made huge strides in treating heart disease in the 20th century, from drug-eluding stents to automatic internal defibrillators. Public awareness of the dangers of heart disease has never been more pervasive. Now, though, ten years into a new millennium, scientists are gearing up for the next great challenges in tackling this pervasive condition. Cell therapy is going to be a key weapon in the fight against heart disease. It has the potential to address many cardiovascular conditions. From heart failure to atrioventricular nodal dysfunction, the young but promising field of cell therapy is set to play a significant role in developing the cures that the upcoming decades of hard work will yield.Regenerating the Heart: Stem Cells and the Cardiovascular System organizes the field into a digestible body of knowledge. Its four sections cover mechanical regeneration, electrical regeneration, cardiac tissues and in vivo stem cell therapies. An array of talented researchers share the fruits of their labors, with chapters covering such crucial issues as the cardiogenic potential of varying stem cell types, the ways in which they might be used to tackle arrhythmias, their possible application to biological replacements for cardiac tissues such as valves, and the varying approaches used in the in vivo evaluation of stem cell therapies, including methods of delivering stem cells to the myocardium. This comprehensive survey of an area of research with such exciting potential is an invaluable resource both for veteran stem cell researchers who need to monitor fresh developments, and for newly minted investigators seeking inspirational
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    Cardiovascular Physiology Concepts (Lippincott Connect) Third Edition

    Original price was: $49.00.Current price is: $39.00.

    Cardiovascular Physiology Concepts (Lippincott Connect) Third Edition

    Lippincott® Connect Featured Title Purchase of the new print edition of this Lippincott® Connect title includes access to the digital version of the book, plus related materials such as videos and multiple-choice Q&A and self-assessments.Praised for its concise coverage, this highly accessible monograph lays a foundation for understanding the underlying concepts of normal cardiovascular function and offers a welcome alternative to a more mechanistically oriented approach or an encyclopedic physiology text. Clear explanations, ample illustrations and engaging clinical cases and problems provide the perfect guidance for self-directed learning and prepare you to excel in clinical practice.
    • Chapter Learning Objectives highlight key concepts at a glance.
    • Problems and Clinical Cases with Answers to Problems reinforce fundamental physiological concepts.
    • Summary of Important Concepts boxes provide bulleted quick-review of essential chapter content.
    • Multiple-choice Review Questions and Answers to Review Questions (with full explanations for each answer choice) enable self-assessment and alert you to areas requiring further study.
    • A chapter on Cardiovascular Integration, Adaptation, and Pathophysiology integrates cardiovascular concepts in the context of normal and clinically relevant conditions.
    Lippincott® Connect features:
    • Full access to the digital version of the book with the ability to highlight and take notes on key passages for a more personal, efficient study experience. 
    • Carefully curated resources, such as interactive diagrams, audio and video tutorials, and self-assessment, all designed to facilitate further comprehension. 
    Lippincott® Connect also allows users to create Study Collections to further personalize the study experience. With Study Collections you can:
    • Pool content from books across your entire library into self-created Study Collections based on discipline, procedure, organ, concept or other topics. 
    • Display related text passages, video clips and self-assessment questions from each book (if available) for efficient absorption of material. 
    • Annotate and highlight key content for easy access later. 
    • Navigate seamlessly between book chapters, sections, self-assessments, notes and highlights in a single view/page. 
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    Genes and Cardiovascular Function

    Original price was: $203.00.Current price is: $150.00.

    Genes and Cardiovascular Function

    by Bohuslav Ostadal (Editor), Makoto Nagano (Editor), Naranjan S. Dhalla (Editor) Rapid advances in molecular medicine have led to pronounced new developments in experimental and clinical cardiology.  In the embrace of modern molecular biology and bridging the gap between the clinical and the genomic, cardiovascular medicine has seen major strides in the understanding of the molecular mechanisms that drive disease progression.  The ability to rapidly identify candidate human genes for cardiovascular diseases lends itself to the development of diverse strategies for disease treatment and management.  The wide variety of gene expressions proffers excellent targets for novel therapeutics.  Gene therapy is steadily increasing in viability and represents a fascinating arena of research and clinical focus. This book is based on two international Mendel symposia on “Genes and the Heart,” joint meetings of the Japanese and European sections of the International Academy of Cardiovascular Sciences.  Highlighting selected symposia contributions, this book explores the role of molecular biology and genetics in the basic knowledge, genesis, and clinical interventions of cardiovascular diseases.
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    Molecular Defects in Cardiovascular Disease

    Original price was: $243.00.Current price is: $190.00.

    Molecular Defects in Cardiovascular Disease

    A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology.  It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies.
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    Applications of Biotechnology in Cardiovascular Therapeutics

    Original price was: $189.00.Current price is: $150.00.

    Applications of Biotechnology in Cardiovascular Therapeutics

    For physicians, surgeons, and scientists working on cardiovascular disorders, Applications of Biotechnology in Cardiovascular Therapeutics serves as an invaluable reference by collecting the essential writings of Dr. Kewal K. Jain on the topics of biotechnology as they relate to cardiovascular disease.  This thorough volume includes such subjects as biotechnology and therapeutic delivery to the cardiovascular system, cell-selective targeted drug delivery, cell and gene therapies, including antisense and RNA interference, cutting-edge gene therapy approaches, as well as personalized cardiology as a way of integrating new technologies into the selection of the best possible treatment for an individual patient.  Selected references from recent literature are collected for each chapter, and the text is supplemented by a variety of useful tables and figures. Comprehensive and up-to-date, Applications of Biotechnology in Cardiovascular Therapeutics will be tremendously useful for those working in life sciences and the pharmaceutical sciences, and the inclusion of some basics of cardiovascular diseases will greatly benefit nonmedical readers as well.
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    A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases

    Original price was: $50.00.Current price is: $40.00.

    A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases

    by Committee on a National Surveillance System for Cardiovascular and Select Chronic Diseases (Author), Institute of Medicine (Author)Chronic diseases are common and costly, yet they are also among the most preventable health problems. Comprehensive and accurate disease surveillance systems are needed to implement successful efforts which will reduce the burden of chronic diseases on the U.S. population. A number of sources of surveillance data--including population surveys, cohort studies, disease registries, administrative health data, and vital statistics--contribute critical information about chronic disease. But no central surveillance system provides the information needed to analyze how chronic disease impacts the U.S. population, to identify public health priorities, or to track the progress of preventive efforts.A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases outlines a conceptual framework for building a national chronic disease surveillance system focused primarily on cardiovascular and chronic lung diseases. This system should be capable of providing data on disparities in incidence and prevalence of the diseases by race, ethnicity, socioeconomic status, and geographic region, along with data on disease risk factors, clinical care delivery, and functional health outcomes. This coordinated surveillance system is needed to integrate and expand existing information across the multiple levels of decision making in order to generate actionable, timely knowledge for a range of stakeholders at the local, state or regional, and national levels.The recommendations presented in A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases focus on data collection, resource allocation, monitoring activities, and implementation. The report also recommends that systems evolve along with new knowledge about emerging risk factors, advancing technologies, and new understanding of the basis for disease. This report will inform decision-making among federal health agencies, especially the Department of Health and Human Services; public health and clinical practitioners; non-governmental organizations; and policy makers, among others.
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    A Practical Approach to Cardiovascular Medicine

    Original price was: $85.00.Current price is: $65.00.

    A Practical Approach to Cardiovascular Medicine

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    Atherosclerotic Cardiovascular Disease

    Original price was: $140.00.Current price is: $110.00.

    Atherosclerotic Cardiovascular Disease

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    Cardiovascular Critical Care

    Original price was: $157.00.Current price is: $100.00.

    Cardiovascular Critical Care

    by Mark J.D. Griffiths (Editor), Jeremy Cordingley (Editor), Susanna Price (Editor) Remarkable improvements in cardiac survival rates have made cardiovascular critical care much more common, but no less challenging for the practitioner. This important volume draws on the skills of an expert team of editors and contributors to present a timely overview of clinical practice.The book covers the full range of the field, from pre-operative assessment and the haematological complications of cardiovascular surgery and critical care to the care of patients with:·         Arrhythmias·         Heart Failure·         Adult Congenital Heart Disease·         Mitral Valve Disease·         Aortic Valve Disease·         Infective Endocarditis·         VasculitisThe authors also address the special problems associated with the management of conditions consequent upon pregnancy, eclampsia, and the hypertensive crisis.With high-quality illustrations and a helpful index, Cardiovascular Critical Care gives you access to information that helps you provide the best possible care to your patients.
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    Cardiovascular Effects of Inhaled Ultrafine and Nanosized Particles

    Original price was: $189.00.Current price is: $140.00.

    Cardiovascular Effects of Inhaled Ultrafine and Nanosized Particles

    by Flemming R. Cassee  (Editor), Nicholas L. Mills (Editor), David E. Newby (Editor)
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    Practical Cardiovascular Pathology 3rd Edition

    Original price was: $191.00.Current price is: $150.00.

    Practical Cardiovascular Pathology 3rd Edition

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    MRI of Cardiovascular Malformations

    Original price was: $109.00.Current price is: $70.00.

    MRI of Cardiovascular Malformations

    MRI is a non-invasive and non-ionizing imaging modality that is perfectly suited for the diagnosis and follow-up of both pediatric and adult congenital heart disease. It provides a large field of view and has the unique ability to depict complex cardiac and vascular anatomy and to measure cardiac function and flow within one examination. MRI is the ideal complement to echocardiography whenever the information provided by the latter is limited. This book has been conceived as a self-teaching manual that will assist qualified radiologists, cardiologists, and pediatricians, as well as those in training. It is richly illustrated with numerous images and drawings that cover all usual and most unusual anomalies. The principal author, Professor Bruno Kastler, is head of radiology at Besançon University Hospital, France and is board certified in both radiology and cardiology.
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    Horizons in World Cardiovascular Research Volume 3

    Original price was: $206.00.Current price is: $150.00.

    Horizons in World Cardiovascular Research Volume 3

  • Sale!

    Advanced Cardiovascular Exercise Physiology Second Edition

    Original price was: $119.00.Current price is: $90.00.

    Advanced Cardiovascular Exercise Physiology Second Edition

    Advanced Cardiovascular Exercise Physiology, Second Edition, systematically details the effects of acute and chronic exercise training on each component of the cardiovascular system: the heart, the vasculature, and the blood (including blood clotting factors). Students and professionals working within exercise science and related health professions will gain a comprehensive understanding of the cardiovascular system and learn how to apply this knowledge to their work.Advanced Cardiovascular Exercise Physiology, Second Edition, highlights the complex interaction of the components of the cardiovascular system, both at rest and during exercise. Using the latest scientific and medical research, this text presents an engaging discussion of cardiovascular responses and adaptions to both aerobic and resistance exercise training, and it offers readers possible future directions for research. Specific attention is paid to the beneficial effects of exercise and the mechanisms through which regular exercise promotes cardioprotection. The second edition incorporates new topics and expanded information on the following:
    • Ventricular hypertrophy
    • Central blood pressure and its measurement
    • Pathophysiology of arterial stiffness and relevant measurement techniques
    • Blood pressure during exercise and its clinical importance
    • The effects of prolonged acute exercise on cardiac arterial and hemostatic function
    • Endothelial function, including the impact of aging and sex, and potential mechanisms
    • An individual’s response and adaptation to both resistance training and aerobic training
    The second edition of Advanced Cardiovascular Exercise Physiology uses a larger format to showcase its richly illustrated contents. Updated figures and graphics visually elucidate physiological mechanisms to depict exercise responses and training adaptations. Each chapter begins with chapter objectives and ends with a summary to help students retain important content. Fifteen case studies are included in the text to showcase the application of chapter material. Key terms are boldfaced throughout the text and are defined at the end of each chapter. In addition, sidebars describe real-world examples and applications.This text is divided into two sections. The first section offers a concise explanation of the structure and function of each component of the cardiovascular system. In the second section, readers encounter a detailed discussion of the acute and chronic effects of aerobic and resistance exercise on cardiac function, vascular function, and hemostatic variables.Advanced Cardiovascular Exercise Physiology, Second Edition, provides a framework for understanding how the components of the cardiovascular system cooperate to support exercise and how those components adapt to and benefit from a systematic program of exercise training.

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    Cardiovascular Pharmacotherapeutics 3rd Ed

    Original price was: $120.00.Current price is: $90.00.

    Cardiovascular Pharmacotherapeutics 3rd Ed

    EVERYTHING PRACTICING PHYSICIANS AND PHARMACISTS NEED TO KNOW ABOUT DRUG THERAPY FOR CARDIOVASCULAR DISEASE<P> A critically acclaimed classic reference now in its third edition, Cardiovascular Pharmacotherapeutics, provides current information regarding the contemporary use of all available cardiovascular medications for adults and children. Strongly emphasizing the scientific rationale behind the use of such cardiovascular therapeutics, it discusses new drugs and novel compounds that are under development and may emerge as the cardiac therapies of the future. This edition also addresses special considerations for drug therapy use in the elderly, during pregnancy, and in those with hepatic or renal disease. A generous assortment of tables, figures, and appendices guides readers in their investigations of each drug group and various disease states.<P>Contents:<P>This edition is organized into 4 main sections.<P>
    1. The introductory section includes chapters related to relevant clinical pharmacology, the placebo effect in cardiovascular disease treatments, patient adherence to pharmacotherapy, and pharmacoeconomics.
    2. The available cardiovascular drugs are reviewed, and each class of drugs is organized into separate chapters. In these chapters the reader will find detailed discussions on how to use individual drugs for prevention and treatment. New drugs in development for each class of agents are also reviewed. Compared to the first 2 editions, the editors have provided hundreds of updated reference citations, as well as adding new chapters on drugs for pulmonary hypertension, vasopressin and vasopressin antagonists, and drug-eluting stents. Since cardiovascular clinicians do not practice in a vacuum, there are also chapters in this section that deal with the pharmacotherapy of obesity, diabetes mellitus, and smoking cessation as it relates to the cardiac patient.
    3. Special topics related to cardiovascular pharmacotherapy that the clinician will often encounter and includes chapters on alternative and complementary medicine, cardiovascular drug drug interactions, pediatric cardiovascular pharmacology, antibiotic prophylaxis and treatment guidelines for endocarditis and rheumatic fever, and drug therapy of cerebrovascular and peripheral vascular diseases. The section concludes with a chapter on cytokines and myocardial regeneration as a new therapeutic option for cardiac disease and a final chapter that summarizes the status of more than 200 agents that are currently in clinical trials as innovative treatments for cardiovascular disease.
    4. 8-part appendix provides practical, hands-on information on using drugs in clinical settings.
      • Provides relevant pharmacokinetic information regarding all the available cardiovascular drugs.
      • Offers practical drug prescribing information.
      • Guides for using cardiovascular drugs in specific patient populations.
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    Challenging Concepts in Cardiovascular Medicine Cases with Expert Commentary

    Original price was: $95.00.Current price is: $70.00.

    Challenging Concepts in Cardiovascular Medicine Cases with Expert Commentary

    by Aung Myat (Author, Editor), Shouvik Haldar (Author, Editor), Simon Redwood (Author, Editor) A comprehensive guide to the assessment, diagnosis, investigation and management of complex clinical scenarios in cardiovascular medicine.This book contains a series of challenging concepts in cardiovascular medicine covering all subspecialty areas including general cardiology, intervention, cardiac imaging, electrophysiology, heart failure and cardiomyopathies, cardiac devices, transplant medicine, epidemiology, heart disease in pregnancy and congenital heart disease. Each case provides an in-depth review of current practice, the application of national and international guidelines and a summary of evidence from the medical literature. Data sets, investigation results and cardiac imaging give the reader a 'real-life' sense of being in the outpatient clinic, emergency room, coronary care unit or cardiac catheterisation laboratory. Each case is punctuated by 'Clinical Tips', 'Learning Points' and 'Landmark Trial Summaries' to enhance the learning process alongside an 'Expert Commentary' written by internationally-renowned leaders in the field of cardiology.
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    Principles of Vascular Ultrasound

    Original price was: $84.00.Current price is: $60.00.

    Principles of Vascular Ultrasound

    by Stuart J. Hutchison  (Author), Katherine C. Holmes (Author) Principles of Vascular and Intravascular Ultrasound—a title in the Principles of Cardiovascular Imaging series—has everything you need to successfully obtain and interpret vascular ultrasound images. Stuart J. Hutchison—a premier cardiac imaging specialist—explains the dos and don’ts of ultrasound so you get the best images and avoid artifacts. Get only the coverage you need with clinically oriented, practical information presented in a consistent format that makes finding everything quick and easy.
    • Focuses on clinically oriented and practical information so that you get only the coverage that you need.
     
    • Explains how to obtain the best image quality and avoid artifacts through instructions on how to and how not to perform vascular ultrasound.
     
    • Provides excellent visual guidance through high-quality images—many in color—that reinforce the quality of information in the text.
     
    • Includes numerous tables with useful values and settings to help you master probe settings and measurements.
     
    • Presents material in a consistent format that makes it easy to find information.
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    Principles of Cardiovascular Radiology

    Original price was: $87.00.Current price is: $60.00.

    Principles of Cardiovascular Radiology

    by Stuart J. Hutchison  (Author) Principles of Cardiovascular Radiology—a title in the Principles of Cardiovascular Imaging series—has everything you need to successfully obtain and interpret chest X-rays. Stuart J. Hutchison—a premier cardiac imaging specialist—covers each category of cardiac conditions and provides numerous high-quality schematic and clinical images side by side for comparison. Get only the coverage you need with clinically oriented, practical information presented in a consistent format that makes finding everything quick and easy.
    • Focuses on clinically oriented and practical information so that you get only the coverage that you need.
     
    • Presents material in a consistent format that makes it easy to find information.
     
    • Provides excellent visual guidance through high-quality images that reinforce the quality of information in the text.
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    Fetal Cardiovascular Imaging A Disease Based Approach

    Original price was: $354.00.Current price is: $300.00.

    Fetal Cardiovascular Imaging A Disease Based Approach

    Fetal Cardiovascular Imaging, edited by Drs. Rychik and Tian, is the most complete video atlas available in this field – providing the detailed visual guidance you need to successfully identify a full range of fetal heart disorders. Complied by the team at the Cardiac Center at Children’s Hospital in Philadelphia, this Expert Consult site and accompanying atlas-style text guide the acquisition and interpretation of fetal images for accurate diagnosis and effective management. Vivid color images, drawings, pathologic specimens and diagnostic algorithms facilitate tracking the progress of development of over 100 fetal heart problems.
    • Enhance your cardiac imaging skills with a video library demonstrating imaging of the normal heart, and the imaging presentation of more than 100 different fetal heart problems.
     
    • Recognize potential problems using views of the normal heart in development for comparative diagnosis.
     
    • Get comprehensive coverage of cardiac anatomy, pathophysiology, natural history and disease management.
    See developing and existing problems as they appear in practice thanks to an abundance of vivid color images, drawings, pathologic specimens, and diagnostic algorithms.Track the progress of development in the fetal heart by using the best imaging modalities & techniques for more accurate diagnosis.
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    Cardiovascular Imaging

    Original price was: $174.00.Current price is: $120.00.

    Cardiovascular Imaging

    Cardiovascular Imaging, a title in the Expert Radiology Series, edited by Drs. Vincent Ho and Gautham P. Reddy, is a comprehensive 2-volume reference that covers the latest advances in this specialty. It provides richly illustrated, advanced guidance to help you overcome the full range of diagnostic, therapeutic, and interventional challenges in cardiovascular imaging and combines an image-rich, easy-to-use format with the greater depth that experienced practitioners need. Online access at www.expertconsult.com allows you to rapidly search for images and quickly locate the answers to any questions.
    • Access the fully searchable text online at www.expertconsult.com, along with downloadable images.
     
    • View 5000 full-color digital images of both radiographic images and cutting-edge modalities―MR, multislice CT, ultrasonography, and nuclear medicine.
     
    • Tap into comprehensive coverage that includes diagnostic and therapeutic options, with an emphasis on cost-effective imaging.
     
    • Consult the experience of a diverse group of experts on cardiovascular imaging from around the globe.
     
    • Find information quickly and easily thanks to consistent and tightly focused chapters, a full-color design, and key points boxes.
    Comprehensive cardiovascular imaging reference for best patient outcomes
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    Nanomedicine and the Cardiovascular System

    Original price was: $220.00.Current price is: $170.00.

    Nanomedicine and the Cardiovascular System

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    Cardiovascular MRI in Congenital Heart Disease

    Original price was: $139.00.Current price is: $110.00.

    Cardiovascular MRI in Congenital Heart Disease

    by Shankar Sridharan (Author), Gemma Price (Author), Oliver Tann (Author), Marina Hughes (Author), Vivek Muthurangu (Author), Andrew M. Taylor (Author)
    The last 10 years has seen explosive expansion of the number of centres performing cardiov- cular magnetic resonance (CMR) imaging. The majority of this expansion has been in the ? eld of adult ischaemic imaging, but congenital heart disease remains one of the main indications for CMR. Importantly, the greatly improved survival of patients with congenital heart disease gives us a burgeoning adult population living with the sequelae of the disease (grown-up c- genital heart disease – GUCH). Without previous experience or formal training, the interpretation of CMR images of patients with congenital heart disease can be dif? cult. The main aim of this book is to create a portable resource that offers ef? cient access to high-quality MR (and where appropriate, CT) images of the common congenital and structural heart abnormalities. We hope that by prov- ing key images for each condition and a clear interpretation of the MR appearances, we will improve the reader’s understanding of the conditions, facilitate their interpretation of images and optimise the planning of the imaging protocols during their own practice of congenital CMR. As with any publication from a single institution, the contents of this book represent our own practice. We have not written a de? nitive or exhaustive description of the conditions.
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    Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems

    Original price was: $199.00.Current price is: $150.00.

    Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems

    by Antonio Giordano (Editor), Umberto Galderisi (Editor)
    Complex physiopathological relationships have been proven to exist between two of the body’s most vital organs; the brain and the heart. In Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems Antonio Giordano, Umberto Galderisi and a panel of the most respected authorities in their field offer an in-depth analysis of the differentiation process in two systems that have profound relationships with one another. The text looks at several aspects of the cardiovascular and nervous systems from a new point of view, describing the differences and similarities in their differentiation pathways with an emphasis on the role of cell cycle regulation and cell differentiation. Topics discussed include neurogenesis in the central nervous system, neural stem cells, and the basic-helix-loop-helix transcription factors in neural differentiation. Ground-breaking and authoritative, Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems is a must have for all researchers in cardiovascular medicine and neuroscience and will prompt the scientific community to perceive cell cycle regulation and differentiation under a novel and more comprehensive light.
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    Computational Cardiovascular Mechanics Modeling and Applications in Heart Failure

    Original price was: $167.00.Current price is: $120.00.

    Computational Cardiovascular Mechanics Modeling and Applications in Heart Failure

    by Julius M. Guccione (Editor), Ghassan Kassab (Editor), Mark B. Ratcliffe (Editor)Computational Cardiovascular Mechanics provides a cohesive guide to creating mathematical models for the mechanics of diseased hearts to simulate the effects of current treatments for heart failure. Clearly organized in a two part structure, this volume discusses various areas of computational modeling of cardiovascular mechanics (finite element modeling of ventricular mechanics, fluid dynamics) in addition to a description an analysis of the current applications used (solid FE modeling, CFD). Edited by experts in the field, researchers involved with biomedical and mechanical engineering will find Computational Cardiovascular Mechanics a valuable reference.
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    The Cardiovascular System

    Original price was: $48.00.Current price is: $30.00.

    The Cardiovascular System

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    Cardiotoxicity of Non Cardiovascular Drugs

    Original price was: $183.00.Current price is: $140.00.

    Cardiotoxicity of Non Cardiovascular Drugs

    Some drugs which are not aimed at treating heart disease have nevertheless been found to have profound effects on heart muscle. Cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals.In recent years a number of non-cardiac blockbuster drugs such as terfenadine have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been withdrawn prior to marketing or required labelling changes that significantly restricted their use.In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. Topics include:
    •  metabolic targets of cardiotoxicity
    • regulatory aspects
    • translating molecular mechanisms into clinical trials
    • structure-activity relationships in arrhythmias by antihistamines and psychoactive drugs
    • cardiovascular toxicity of antitumor drugs
    • cardiovascular toxicities of non-steroidal anti-inflammatory drugs
    • cardiovascular toxicities of antiretroviral therapies
    Cardiotoxicity of Non-Cardiovascular Drugs is an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy and cardiovascular disease
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    Studies on Cardiovascular Disorders

    Original price was: $205.00.Current price is: $150.00.

    Studies on Studies on Cardiovascular Disorders

    by Heinrich Sauer (Editor), Ajay M. Shah (Editor), Francisco R. M. Laurindo (Editor)The role of reactive oxygen species (ROS) in the cardiovascular system is Jan- faced. Whereas low concentrations of ROS are involved in variety of physiological signalling events, oxidative stress resulting from deregulated overproduction of ROS and/or impaired antioxidant defences contributes to cardiovascular disease. The actions of ROS in the cardiovascular system are a fascinating topic, not only for the basic science researcher but also for the clinician who is interested in seeking new therapies for his patients suffering from cardiovascular disease. The current book provides a comprehensive overview of the molecular mechanisms and pathoph- iological settings in which chronic and detrimental oxidative stress arises within the heart and vasculature. The book also considers currently discussed strategies in avoiding chronic redox stress resulting from exposure to risk factors or various cardiovascular interventions. The series starts with an overview by Denise de Castro Fernandes, Diego Bonatto and Francisco Laurindo of redox signaling models that could underlie the dev- opment of redox-associated cardiovascular disorders. The interactions of proteins within signalling cascades with ROS and the regulation of such interactions by the anti-oxidative capacity of the cell are discussed. Rebecca Charles, Joseph Burgoyne and Philip Eaton report on redox-mediated modi cations of proteins under ph- iological and pathophysiological conditions and the variety of post-translational oxidative modi cations that explain redox sensing and signal transduction by proteins at the molecular level. ROS are generated during embryogenesis and may be involved in the proper development of the cardiovascular system.
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    Cardiovascular Magnetic Resonance: A Companion to Braunwald’s Heart Disease 3rd Edition

    Original price was: $189.00.Current price is: $150.00.
    Colour Matt Finshed
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    Renin Angiotensin System and Cardiovascular Disease

    Original price was: $66.00.Current price is: $40.00.

    Renin Angiotensin System and Cardiovascular Disease

    by Walmor C. DeMello (Editor), Edward D. Frohlich (Editor)Experimental and clinical evidence supports the view that the activation of the renin angiotensin aldosterone system is involved in cardiovascular pathology including hypertension, heart failure, myocardial ischemia, and atherosclerosis. The present volume describes the intricacies involved in these processes, including the in?uence of prorenin/renin, angiotensin II, angiotensin (1-7), and aldosterone on cardiac and vascular functions as well as their involvement in the generation of cardiovascular diseases. Fundamental aspects like intracellular signaling, regulation of cell volume in the failing heart, and the presence of an intracrine renin angiotensin system are discussed. Moreover, the role of the mineralocorticoid receptor as an important c- ponent of the intracrine renin angiotensin system and as a regulator of extracellular action of angiotensin II is described, reinforcing the view that aldosterone inhibitors are helpful in the treatment of heart failure and hypertension. Let us hope the imp- tant topics included here motivate basic and clinical investigators and contribute to the development of new therapeutic approaches for cardiovascular diseases. We want to thank the distinguished authors and Humana Press for the opportunity to publish this important book. Walmor C. DeMello Edward Frohlich v Contents 1 Systemic Versus Local Renin Angiotensin Systems. An Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Walmor C. DeMello and Richard N. Re 2 Clinical Import of the Local Renin Angiotensin Aldosterone Systems . . . . . . . . . . . . . . . . . . . . . . . . . 7 Edward D. Frohlich 3 Renin, Prorenin, and the (Pro)Renin Receptor . . . . . . . . . . . 15 Genevieve Nguyen and Aurelie Contrepas 4 Local Renin Angiotensin Systems in the Cardiovascular System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 Richard N.
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    Patient Specific Modeling of the Cardiovascular System Technology Driven Personalized Medicine

    Original price was: $163.00.Current price is: $120.00.

    Patient Specific Modeling of the Cardiovascular System Technology Driven Personalized Medicine

    by Roy C.P. Kerckhoffs (Editor) Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.